So looked around and found the main things people are having issues with in the new layout - these might be things to improve on or fix;
Topic Suggestions;

Topic suggestions are not really needed at the top of the main page. given we have suggested topics at the bottom of each topic. I've had little-to-no interactions with the suggested topics either, so not sure why some are being suggested. Other 'Hot topics' feel like they shouldn't really be focused because of their nature as troll topics, fun to mess-around with, but not really something that should be thrown in a member's face when they log in
They are also incorrectly labelled saying they were updated years ago. It also appears to be scrolling, yet there is no option to scroll back. So if you notice a topic you are interested in, chances are you'll miss it as it'll scroll before you click it.
There is also the idea that it may reveal spoilers for people who don't want to see them when suggesting topics about varying things - such as Ninjago or other TV shows/films which sometimes have a spoiler-filled image inserted in the opening post on the topic. (Seen this happen with the Ninjago realms topic)
A a similar 'text-based' suggested topic, to what is currently shown at the bottom of pages would fix this issue and take-up less space.
Making the 'hot topics' shown be the starred topics which have been starred by staff would fix most the issues with them - user topics would still be suggested at the bottom of topics.
Profile pic sizes;

Sizes of the profile pics have changed again, resulting in the issue mentioned by 'The_Owl' where its difficult to see the profile pictures. I think its also trimmed a few images resulting in the above image of 'Kah' and the unreadable 'Cast & Crew'
Pictures and videos posted compared to text;

As shown and probably demonstrated here, pictures and videos posted come out as massive taking up the entire space of the comment while text fills barely a corner of a massively long comment box and seems squished sometimes in the previews and when posting.
Pictures not posting;
Sometimes imgur links will not post the image despite it working in the previews.
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Personally, could get used to the layout other than the annoying, scrolling 'hot topic' bar that will forever be known as 'Steve'