I mean, theoretically, yes. In practicality, no. See, human characters in particular have a weird relationship with this franchise. They’ve been a part of the brand since day one, a way to make the autobots more relatable and approachable by having them befriend a human everyman audience surrogate. The problem that you run into is that humans are squishy and weak, particularly regular civilians, so in practise they tend to end up getting in the way of every encounter they’re involved in, and considering how often characters fight in transformers, it… becomes a problem.
Ontop of just the general pitfalls of character writing (which are slightly skewed anyway since generally in an attempt to appeal to children they come out… obnoxious, Sam and Miko meanwhile have no excuse, they’re just bad ), you have this initial inherent hurdle you have to go over, ie justifying their inclusion in the story at all beyond an initial audience surrogate, which leads to them getting a lot of screentime, which depending on the character can be anywhere from slightly irritating to single-handedly making the show unwatchable for some people.
With only transformers to work with, you essentially can just treat them as humans with extra bells and whistles now that they’re all generally on the same scale, which means you can just, like, tell a story. Will this always be a good story? Hell no, just look at those godawful machinama animations. But it’s no longer going to be dragged down by a tagged-on human subplot.
In the case of bayformers however, yes, they did make a huge mistake by putting so much focus on human characters, to the point where the actual transformers, you know, the thing people came to see, end up just being a pretty background feature that pop up now and then to spew some garbage dialogue and act like one-dimensional a-holes (then again, everyone in bayformers is a one-dimensional a-hole, but the transformers themselves are a particularly egregious example). If they tried to focus on those transformers without any humans? Yeah, that would just be a terrible movie. But I consider that more a fault of the writers for not really understanding what they were working with rather than an inherent flaw with the brand.
Bumblebee has demonstrated however that this new team is capable of actually writing the transformers as characters, so we should probably be fine.