What if the Children of Atom aren't wrong? What if there is some sort of driving force behind radiation the Fallout Universe?
In the Dunwich Borers, the pre-war cultists of some kind all ended up becoming Ghouls from radiation, and the player gets weird flashbacks. In Point Lookout, there's a legit cursed book and ancient deity that goes back even before the war that the cultists there worship. In Far Harbor, it seems like the creatures are spawned from the fog itself, and that the fog has its own will (all of this refers to some sort of Lovecraftian lore for inspiration).
I know there are some Fallout fans that want the series to be super serious and grounded, but it's never been like that, and they need to accept that. We've had people somehow develop psychic powers, and there are even a few ghosts (and this is as far back as Fallout 2, meaning it isn't all just Bethesda). I personally like the take that perhaps through all of mankind's obsession to understand the universe in the Fallout Universe, and their need to use that knowledge to dispel their fear of things that are outside the boundaries of life's binary patterns, that they end up being in denial of anything outside of the rational.
Honestly, I'd like some pre-war journal entries to survive in good condition and read something like this:
"Perhaps mankind's greatest flaw is its binary look at life. The need to categorize and dissect. For the longest time, humans have spent their lives dissecting the universe and using that knowledge to boost their confidence, for they fear a world that isn't binary. They forget though, that they are merely a product if a binary lifestyle. Day to night. Birth to death. They only see the rational, because that's all their feeble minds can handle, less they go mad from the prospect of a never-ending current. They're wrong though. They're not the first to set foot here, and they certainly won't be the last. The universe, time itself, it doesn't start, it doesn't end. It's not binary like the atoms that make up all matter. Matter is merely the coding of everything around us, and coding can be manipulated and extorted by sources that isn't held down by it. What humans fear most isn't inherently the unexplainable. It's what the unexplainable draws forth from the shadowy crevices of the universe. Holes that look into a very different plane of existence where there are powers beyond you or me. The easiest way to break a human is to put a crack in its binary processing. Perhaps one day, they'll look into the abyss, and they'll see the First Ones looking back"
It's just always nice to have those things in the background, adding mystery and awe to the world, because people who don't like it can just as easily ignore it, while those of us that want a story that doesn't ground itself too heavily to the conventions of reality can have something nice to spice things up.