Details on Protodermis Synthesis?

Does creating Protodermis require Energized Protodermis, or is someone with knowledge of the substance capable of synthesizing it without EP?

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I think Greg said at one point that the Great Beings had developed normal protodermis before finding EP?

You don’t need EP to make protodermis.

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So any MU resident could do it with the right resources and/or equipment, like the Shadowed One and his staff?

Thanks, some of the sources I was looking at were slightly inconsistent on that.