That'd be awesome.
See, I prefer Gwen Stacy, but since she kinda has a death requirement, and is only really cool in Spectacular Spider-Man and the Spider Gwen comics, (since she hasn't been in 616 since, what, the clone saga?), Mary Jane is a better love interest for the big screen.
Just as long as it's better than the Maguire films...
(Could you at least try not to hang off the edge of a building and scream?)